Pharmacogenomics
Pharmacogenomics: the convergence of pharmacology and genetics dealing with genetically determined responses to drugs. |
The Pharmacogenomics class was originally offered as a week-long intensive class, Oct. 17-20, 2005 at the University of the Western Cape as part of the SSABMI program training. The class was offered again, July 2006, at Stanford, at which time, the lectures were taped. We will ship class materials including DVD's upon request. For educational institutions in South Africa and programs in developing countries funded by the Fogarty International Center, we will sent all Pharmacogenomics class materials at no cost. For all other requests, there will be a shipping and handling charge.
| Order Pharmacogenomics DVD's (free) | Order Pharmacogenomics DVD's (s&h fee) |
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Sample the video
Download the first 10 minutes of the introductory Pharmacogenomics lecture (38.1 MB mp4 file - You will need Real Player, QuickTime, iTunes or other compatible video player to view). This mp4 file has been reduced in resolution and size from the original DVD for faster downloads.
Instructors
Russ B. Altman, M.D., Ph.D., Professor of Medicine, Genetics, Bioengineering, and, by courtesy, Computer Science at Stanford University
Caroline F. Thorn, Ph.D., currently with the American Association for Cancer Research, former curator PharmGKB
The Pharmacogenomics course introduces students to informatics applications in the area, with a special focus on the PharmGKB database, a publicly available internet research tool developed by Stanford University to aid researchers in understanding how genetic variation among individuals contributes to differences in reactions to drugs. Class sessions will be a mixture of lectures, demonstrations and exercises. All sessions are pre-recorded. The videos are available on DVD. At the present time, we ask you to distribute the lecture slides in hard copy only, due to copyright considerations. Pharmacogenomics lecture slides (you will be directed to the PharmGKB website)
Class Topics
- Introduction to Pharmacogenomics (PGX), the Genome and Genetics
- Human Polymorphisms, frequencies, significance and populations
- Basic Pharmacology
- Informatics in PGX
- Classical Examples
- Genotype to phenotype approaches and phenotype to genotype approaches
- Non-classical Pharmacogenomics
- How drugs are discovered and validated
- Methods for genomic variation discovery & genotyping
- Pharmacogenomics related terminologies & ontologies
- Adverse drug reactions and drug interactions
- Methods for molecular/cellular/clinical phenotypes & data exchange
- Cancer pharmacogenomics Pathways of drug metabolism and action & data exchange
Demonstrations and Exercises
Introduction to PharmGKB, an online resource for pharmacogenomics
Lecture References
- Aithal, G. P., et. al, “Association of polymorphisms in the cytochrome P450 CYP2C9with warfarin dose requirement and risk of bleeding complications”, LANCET, 353 , 717, (1999)
- Chang, J. T., and Altman, R. B., “Extracting and characterizing gene-drug relationships from the literature”, Pharmacogenetics,14, 1, (2004)
- Marshall, E., “Preventing Toxicity with a Gene Test”, Science, 302, 588, (2003)
- Gasche, Y., et. al, “Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism”, N Engl. J. Med., 351, 2827, (2004)
- Rubin, D. et. al, “A Statistical Approach to Scanning the Biomedical Literature for Pharmacogenetics Knowledge”, JAMIA, 12, 121, (2005)
- Weinshilboum, R., “Methyltransferase Pharmacogenetics”, Pharmac. Ther. 43, 77, (1989)
For more information about PharmGKB, including tutorials about Pharmacogenomics and Pharmacogenetics, visit
Prerequisites
Prerequisites include four semesters or quarters of basic biology with preference for cell biology, biochemistry, molecular biology, genetics and genomics. Classes that use textbooks such as “Molecular Biology of the Cell” by Alberts, et. al. are suitable prerequisite classes.
A useful free resource:
Terry Brown. Genomes 2. 2002. A concise reference on molecular biology, with specific focus on genome-era measurement tools. This text is free at ncbi. There is also a third edition but this is not freely available.
For more information about the Pharmacogenomics class at Stanford.
| Order Pharmacogenomics DVD's (free) | Order Pharmacogenomics DVD's (s&h fee) |
|---|
This course is sponsored in part by the PharmGKB project and the Stanford-South Africa Biomedical Informatics Program (SSABMI). The Pharmacogenetics Research Network and Database (PGRN) is financially supported by grants from NIGMS, NHLBI, NHGRI, NIEHS, NCI, and NLM within the NIH, HHS. PharmGKB is managed at Stanford University and is supported by the NIH/NIGMS Pharmacogenetics Research Network and Database (U01GM61374). The SSABMI is a joint training program between Stanford University, University of the Western Cape, University of Cape Town and the National Institute of Communicable Diseases. SSABMI is funded by the Fogarty Center, a section of NIH, under award TW006993.